Are benzodiazepines sperm toxic


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Cytobios. ;36() Induction of sperm head abnormalities in mice by three tranquilizers. Kar RN, Das RK. Toxic effects of diazepam (DZ).

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Drugs and Male Fertility

Induction of sperm head abnormalities in mice by three tranquilizers. - PubMed - NCBI

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Potential parameters of male reproductive toxicity: reproductive performance, testis and sperm analysis in rats given a benzodiazepine derivative, nitrazepam, .

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Description:Abstract The present study was designed to elucidate the correlation between findings from reproductive performance testing and those from histopathological examination of the testis and sperm analysis in rats given a benzodiazepine derivative, nitrazepam, for 2 and 4 weeks. The mechanisms of toxicological action of nitrazepam on the male reproductive organs were also investigated. Treated males were mated to examine reproductive performance with untreated females after each dosing period, and after 4 and 9 week of recovery periods. Necropsy was performed for histopathological examination of the testis and epididymis and for sperm analysis after each dosing period and the final mating trial total of 11 weeks recovery. Concentrations of plasma testosterone and content of testis testosterone in nitrazepam-treated groups were not significantly different from those of controls.

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Views: 2026 Date: 2018-03-03 Favorited: 100 favorites

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